Board Thread:Midian Play-by-Post/@comment-24302820-20150117003323/@comment-24302820-20150417050958

Mostly the discussion is about the mechanics of the thing. The nature of lycanthropy wouldn't change, only the saving throws involved.

Changing Folk are one of the four cultivars of H. Sapiens. For those that are natural-born, being a shapeshifter is totally natural. There are no side-effects, unless we decide to make the Madness something that affects them during adolescence.

Vampire werewolves are totally possible. These two conditions do not interfere with one another, not really. A Changing Folk (natural or infected) can be turned into a Vampire. The reverse is not true, however. As Vampires are immune to disease (by virtue of no longer having a working biology) they cannot contract lycanthropy. Such double-threat characters have all of the benefits and drawbacks of both states. That is, they can shapeshift but are susceptible to the Madness. As Undead, they receive the full benefits of blood purity, as well as gaining dark gifts and flaws. They can turn others into Vampires, though their lack of functioning immune systems (being kind of dead) mean that they no longer transmit lycanthropy. It would be possible as a rare story element--tombs untouched for millennia may hold strange diseases--but not common enough to be reliably transmitted as one would with Undeath.